Description

Boronic Acid, B-(2,3-Dihydro-1H-Indol-6-Yl)- is a specialized organoboron compound featuring an indoline scaffold, making it a valuable building block in modern synthetic chemistry. Its primary value lies in its role as a key intermediate in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for forming carbon-carbon bonds. This high-purity reagent is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Critical building block for synthesizing drug candidates, especially those targeting central nervous system (CNS) disorders, due to the privileged indoline structure.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific heterocyclic frameworks.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as novel polymers and small molecules for OLEDs or sensors.
• Suzuki-Miyaura Cross-Coupling: A fundamental reagent for palladium-catalyzed coupling reactions to create biaryl and heteroaryl structures prevalent in many functional molecules.
• Chemical Biology & Proteomics: Utilized in the development of activity-based probes and inhibitors that target serine hydrolases and other enzymes.
• Ligand Synthesis: Acts as a starting material for preparing sophisticated ligands used in catalysis and metal-organic frameworks (MOFs).

Basic Information

Item	Detail
Product Name	Boronic Acid, B-(2,3-Dihydro-1H-Indol-6-Yl)-
CAS No.	1253912-15-0
Molecular Formula	C8H10BNO2
Molecular Weight	162.98 g/mol
Synonyms	(2,3-Dihydro-1H-indol-6-yl)boronic acid; 6-Indolineboronic acid; 2,3-Dihydro-1H-indole-6-boronic acid; B-(2,3-Dihydro-1H-indol-6-yl)boronic acid; 6-Boronohydrindole; 1H-Indole-6-boronic acid, 2,3-dihydro-; Indoline-6-boronic acid
EINECS	Contact for details

Quality Control

Our Boronic Acid, B-(2,3-Dihydro-1H-Indol-6-Yl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting standards for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.