Description

5-Bromo-Isoquinoline-1-Carboxylic Acid is a high-purity, functionalized isoquinoline derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the versatile 5-bromoisoquinoline scaffold into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting neurological disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that require the isoquinoline pharmacophore.
• Ligand Synthesis: Serves as a starting material for creating sophisticated chelating ligands used in catalysis and material science.
• Functional Material Development: Incorporated into organic electronic materials, such as OLEDs and organic semiconductors, due to its electron-deficient aromatic system.
• Chemical Biology Probes: Utilized to create tagged or modified molecules for studying biological pathways and protein interactions.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form complex biaryl structures.

Basic Information

Product Name	5-Bromo-Isoquinoline-1-Carboxylic Acid
CAS No.	1253654-73-7
Molecular Formula	C10H6BrNO2
Molecular Weight	252.07 g/mol
Synonyms	1-Isoquinolinecarboxylic acid, 5-bromo-; 5-Bromo-1-isoquinolinecarboxylic acid; 5-Bromoisoquinoline-1-carboxylic Acid; 1253654-73-7; 5-Br-IQC; 5-Bromo-1-carboxyisoquinoline
EINECS	Contact for details

Quality Control

Our 5-Bromo-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.