Description

3-(Bromomethyl)-1,1-Difluorocyclobutane is a versatile and highly reactive organofluorine building block. This compound is valued for its unique cyclobutane ring structure functionalized with both bromomethyl and difluoromethylene groups, enabling precise molecular construction. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery and development, particularly for candidates targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the difluorocyclobutane moiety can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and fluorinated materials with unique thermal and chemical resistance properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands and catalysts for asymmetric synthesis and cross-coupling reactions.
• Fluorine-Containing Building Block: Essential for introducing the difluoromethylene (CF2) group into target molecules, a common strategy in medicinal chemistry to modulate lipophilicity and metabolic stability.

Basic Information

Product Name	3-(Bromomethyl)-1,1-Difluorocyclobutane
CAS No.	1252934-30-7
Molecular Formula	C6H9BrF2
Molecular Weight	199.04 g/mol
Synonyms	1,1-Difluoro-3-(bromomethyl)cyclobutane; 3-Bromomethyl-1,1-difluorocyclobutane; (Bromomethyl)difluorocyclobutane; Cyclobutane, 3-(bromomethyl)-1,1-difluoro-; 1,1-Difluorocyclobutane-3-methylene bromide
EINECS	Contact for details

Quality Control

Our 3-(Bromomethyl)-1,1-Difluorocyclobutane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee compliance with your research and process requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its high volatility and sensitivity to strong bases and organic solvents, keep away from heat, sparks, and incompatible materials. Use appropriate grounding procedures when handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.