Description

5-Chloro-4-Cyclopropylthiophene-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines a reactive carboxylic acid group with a halogenated, cyclopropyl-fused thiophene ring system, enabling precise molecular construction. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small-molecule drugs, particularly in therapeutic areas targeting CNS disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Serves as a crucial precursor in the design and synthesis of next-generation herbicides, fungicides, and insecticides with novel modes of action.
• Material Science Research: Used in the development of advanced organic electronic materials, such as novel semiconductors or conductive polymers, due to the electron-rich thiophene core.
• Ligand and Catalyst Development: The carboxylic acid functionality allows for derivatization into complex chelating ligands for catalysis or metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Item	Detail
Product Name	5-Chloro-4-Cyclopropylthiophene-2-Carboxylic Acid
CAS No.	1252900-85-8
Molecular Formula	C8H7ClO2S
Molecular Weight	202.66 g/mol
Synonyms	5-Chloro-4-cyclopropyl-2-thiophenecarboxylic acid; 4-Cyclopropyl-5-chlorothiophene-2-carboxylic acid; 2-Thiophenecarboxylic acid, 5-chloro-4-cyclopropyl-; 5-Chloro-4-cyclopropylthiophene-2-carboxylate; 1252900-85-8; 5-Chloro-4-cyclopropyl-2-thiophenecarboxylate; 4-Cyclopropyl-5-chloro-2-thiophenecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5-Chloro-4-Cyclopropylthiophene-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.