Description

N,4-Dimethyl-1-Benzyl-3-Piperidinamine-D3 is a deuterated analog of a piperidinamine derivative, where specific hydrogen atoms are replaced with deuterium, a stable hydrogen isotope. This deuteration is critical for enhancing metabolic stability and traceability in pharmacokinetic and drug metabolism studies. This high-purity compound is primarily utilized by pharmaceutical R&D teams and analytical laboratories engaged in the development of novel therapeutic agents and advanced analytical methods.

Application

• Pharmaceutical Reference Standard: Serves as a certified internal standard for the precise quantification of its non-deuterated counterpart in complex biological matrices using LC-MS/MS.
• Drug Metabolism and Pharmacokinetics (DMPK): Used as a tracer to study absorption, distribution, metabolism, and excretion (ADME) profiles, leveraging the mass shift provided by the deuterium label.
• Metabolite Identification: Aids in the structural elucidation of drug metabolites by providing a stable isotopic reference point during mass spectrometric analysis.
• Medicinal Chemistry Research: Employed in the synthesis and development of deuterated drug candidates, where deuterium incorporation can improve the metabolic profile and efficacy of lead compounds.
• Analytical Method Development: Essential for validating sensitive and specific bioanalytical assays in compliance with GLP and FDA guidelines.

Basic Information

Product Name	N,4-Dimethyl-1-Benzyl-3-Piperidinamine-D3
CAS No.	1252883-50-3
Molecular Formula	C₁₄H₂₁D₃N₂
Molecular Weight	219.35 g/mol (deuterated form)
Synonyms	1-Benzyl-N,4-dimethyl-3-piperidinamine-d3; 3-Piperidinamine, N,4-dimethyl-1-(phenylmethyl)-, d3; Deutetrabenazine Impurity D3 (potential); Deuterated Piperidinamine Derivative; Benzyl-dimethyl-piperidinamine-d3; [D3]-N,4-Dimethyl-1-benzyl-3-piperidinamine
EINECS	Contact for details

Quality Control

Every batch of N,4-Dimethyl-1-Benzyl-3-Piperidinamine-D3 is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) detailing isotopic purity (D-content), chemical purity (by HPLC), and identity confirmation (by NMR and MS). Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and analytical standard production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider keeping the material under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.