Description

4-(Benzyloxycarbonylamino)Bicyclo[2.2.1]Heptane-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique norbornane-derived bicyclic scaffold. This compound is valued for its role as a critical building block in the synthesis of complex, bioactive molecules, particularly in medicinal chemistry and drug discovery. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new Active Pharmaceutical Ingredients (APIs), especially those targeting central nervous system (CNS) disorders.
• Peptidomimetics & Constrained Peptide Synthesis: Used to introduce rigid, three-dimensional structural elements that enhance metabolic stability and receptor selectivity in peptide-based drug candidates.
• Protease Inhibitor Research: Serves as a core scaffold in the design and synthesis of inhibitors for various proteolytic enzymes.
• Chemical Biology & Probe Development: Employed in creating molecular probes to study enzyme function and biological pathways due to its defined stereochemistry.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective chemical transformations.
• Academic & Industrial R&D: Fundamental research reagent for exploring new chemical space and novel drug-like structures in both university and corporate settings.

Basic Information

Product Name	4-(Benzyloxycarbonylamino)Bicyclo[2.2.1]Heptane-1-Carboxylic Acid
CAS No.	1252672-36-8
Molecular Formula	C16H19NO4
Molecular Weight	289.33 g/mol
Synonyms	1-N-Boc-4-Aminobicyclo[2.2.1]heptane-1-carboxylic acid (related Boc-protected analog); 4-[(Benzyloxy)carbonylamino]bicyclo[2.2.1]heptane-1-carboxylic acid; 4-(Cbz-Amino)bicyclo[2.2.1]heptane-1-carboxylic acid; Cbz-4-Amino-bicyclo[2.2.1]heptane-1-carboxylic acid; (1R,4S)-4-[(Benzyloxycarbonyl)amino]bicyclo[2.2.1]heptane-1-carboxylic acid (stereospecific); (1S,4R)-4-[(Benzyloxycarbonyl)amino]bicyclo[2.2.1]heptane-1-carboxylic acid (stereospecific); N-Cbz-4-Aminonorbornane-1-carboxylic Acid; Z-4-Amino-Norbornane-1-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 4-(Benzyloxycarbonylamino)Bicyclo[2.2.1]Heptane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). For long-term storage, consider storage under inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (for specific enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.