Description

tert-Butyl 5-Aminooctahydro-2H-Isoindole-2-Carboxylate is a high-purity, protected amino acid derivative featuring a rigid bicyclic isoindoline scaffold. This compound is a critical pharmaceutical intermediate and building block for medicinal chemistry research, enabling the synthesis of complex molecules with defined stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly for central nervous system (CNS) targets and peptide mimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile building block for constructing constrained peptide analogs and small molecule libraries for drug discovery.
• Peptidomimetic Development: Used to introduce the 5-aminooctahydro-2H-isoindole-2-carboxylic acid moiety, a scaffold that can enhance metabolic stability and receptor binding affinity.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds or affinity probes for target identification and validation studies.
• Process Chemistry & Scale-Up: Suitable for use in process research and development (PR&D) for optimizing synthetic routes to candidate drugs.

Basic Information

Product Name	tert-Butyl 5-Aminooctahydro-2H-Isoindole-2-Carboxylate
CAS No.	1252572-44-3
Molecular Formula	C₁₃H₂₄N₂O₂
Molecular Weight	240.34 g/mol
Synonyms	5-Amino-1,3,3a,4,5,7a-hexahydro-2H-isoindole-2-carboxylic acid tert-butyl ester; tert-Butyl 5-amino-1,3,3a,4,5,7a-hexahydro-2H-isoindole-2-carboxylate; 2H-Isoindole-2-carboxylic acid, 5-aminooctahydro-, 1,1-dimethylethyl ester; Boc-5-Amino-octahydroisoindole; (3aS,5R,7aR)-tert-Butyl 5-aminohexahydro-1H-isoindole-2(3H)-carboxylate; (3aR,5S,7aS)-tert-Butyl 5-aminohexahydro-1H-isoindole-2(3H)-carboxylate; tert-Butyl cis-5-aminooctahydro-2H-isoindole-2-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Aminooctahydro-2H-Isoindole-2-Carboxylate is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with REACH and other relevant global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.