Description

(5R)-2,2,8,8,9,9-Hexamethyl-3,3-Diphenyl-5-[3-(Trimethylsilyl)-2-Propyn-1-Yl]-4,7-Ddioxa-3,8-Disiladecane is a specialized organosilicon compound featuring a unique chiral center and a protected alkyne functional group. This advanced chemical intermediate is critical for enabling complex synthetic pathways, particularly in the development of novel active pharmaceutical ingredients (APIs) and high-performance materials. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for its role in constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug candidates, particularly in oncology and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides requiring specific stereochemistry for enhanced activity.
• Material Science Research: Serves as a precursor for novel silicon-based polymers, dendrimers, and hybrid organic-inorganic materials.
• Ligand and Catalyst Development: Employed in the creation of chiral ligands and organometallic catalysts for asymmetric synthesis.
• Protecting Group Strategy: The silyl-protected alkyne moiety is utilized in multi-step syntheses where selective deprotection is required.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic and organometallic chemistry.

Basic Information

Product Name	(5R)-2,2,8,8,9,9-Hexamethyl-3,3-Diphenyl-5-[3-(Trimethylsilyl)-2-Propyn-1-Yl]-4,7-Ddioxa-3,8-Disiladecane
CAS No.	1251537-17-3
Molecular Formula	C31H48O2Si4
Molecular Weight	573.07 g/mol
Synonyms	(5R)-2,2,8,8,9,9-Hexamethyl-3,3-diphenyl-5-[3-(trimethylsilyl)prop-2-yn-1-yl]-4,7-dioxa-3,8-disiladecane; (5R)-5-[3-(Trimethylsilyl)prop-2-yn-1-yl]-2,2,8,8,9,9-hexamethyl-3,3-diphenyl-4,7-dioxa-3,8-disiladecane; Chiral Silyl Acetylene Protected Diol Derivative; (R)-TMS-Propargyl Disiloxane Diol Ether; CAS 1251537-17-3; 1,1,1,3,5,5,5-Heptamethyl-3-[(1R)-1-[[3-(trimethylsilyl)-2-propyn-1-yl]oxy]ethyl]trisiloxane, 3,3-diphenyl- (alternative linear representation)
EINECS	Contact for details

Quality Control

Every batch of (5R)-2,2,8,8,9,9-Hexamethyl-3,3-Diphenyl-5-[3-(Trimethylsilyl)-2-Propyn-1-Yl]-4,7-Ddioxa-3,8-Disiladecane is produced and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including chiral purity analysis, to ensure compliance with exacting R&D and process chemistry standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.