Description

Racemic-(3Ar,4S,7As)-tert-Butyl 4-(Aminomethyl)Hexahydro-1H-Isoindole-2(3H)-Carboxylate is a high-purity, protected amine building block of significant interest in advanced organic synthesis. Its value lies in its rigid, bicyclic isoindole scaffold and strategically placed functional groups, making it a versatile intermediate for constructing complex molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, process development, and the synthesis of novel active ingredients. CAS NO 1250993-62-4.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and library synthesis due to its constrained conformation and modifiable amine functionality.
• Peptidomimetics & Scaffold Design: Serves as a rigid, non-natural amino acid surrogate or core structure in the design of bioactive peptides and macrocyclic compounds.
• Agrochemical Synthesis: Employed as a building block in the development of novel pesticides and herbicides with enhanced efficacy and selectivity.
• Catalyst & Ligand Development: Potential precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Academic & Institutional Research: Utilized in universities and research institutes for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	Racemic-(3Ar,4S,7As)-tert-Butyl 4-(Aminomethyl)Hexahydro-1H-Isoindole-2(3H)-Carboxylate
CAS No.	1250993-62-4
Molecular Formula	C15H28N2O2
Molecular Weight	268.40 g/mol
Synonyms	tert-Butyl 4-(aminomethyl)hexahydro-1H-isoindole-2(3H)-carboxylate; (±)-(3aR,4S,7aS)-tert-Butyl 4-(aminomethyl)octahydro-1H-isoindole-2-carboxylate; 4-(Aminomethyl)hexahydro-1H-isoindole-2(3H)-carboxylic acid tert-butyl ester; BOC-protected amino-isoindoline; 1,2,3,3a,4,7a-Hexahydro-4-(aminomethyl)isoindole-2-carboxylic acid tert-butyl ester; (rac)-(3aR,4S,7aS)-2-Boc-4-(aminomethyl)octahydroisoindole; tert-Butyl (rac)-(3aR,4S,7aS)-4-(aminomethyl)octahydro-1H-isoindole-2-carboxylate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC), supported by comprehensive analytical data. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Our quality management system supports development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.