Description

Racemic-(1R,4R,5R)-tert-Butyl 5-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a rigid, functionalized bicyclic scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a versatile chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel therapeutics, particularly in areas like neurology and virology.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly those targeting the central nervous system.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained bicyclic structure and multiple functional handles.
• API Development: Serves as a critical precursor in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective synthesis routes to access enantiomerically pure compounds.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying biological targets and pathways.
• Custom Synthesis Projects: Supplied for contract research and manufacturing (CRO/CMO) projects requiring specialized, high-value intermediates.

Basic Information

Product Name	Racemic-(1R,4R,5R)-tert-Butyl 5-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2-Carboxylate
CAS No.	1250884-35-5
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	tert-Butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate; (±)-(1R,4R,5R)-tert-Butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate; 2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 5-hydroxy-, 1,1-dimethylethyl ester, (1R,4R,5R)-; 2-Boc-5-hydroxy-2-azabicyclo[2.2.1]heptane; 5-Hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester; Bicyclic prolinol derivative; 2-N-Boc-5-hydroxy-2-azabicyclo[2.2.1]heptane
EINECS	Contact for details

Quality Control

Our Racemic-(1R,4R,5R)-tert-Butyl 5-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.