Description

1-Oxo-1,2,3,4-Tetrahydro-Isoquinoline-8-Carboxylic Acid Methyl Ester is a high-purity, synthetically valuable heterocyclic building block and pharmaceutical intermediate. This compound is critical for research and development in medicinal chemistry, particularly for constructing complex molecular scaffolds with potential biological activity. It is primarily sought after by pharmaceutical R&D laboratories, agrochemical companies, and fine chemical manufacturers engaged in the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and combinatorial chemistry libraries to explore new therapeutic avenues.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new herbicides, fungicides, and plant growth regulators.
• Organic Synthesis Reagent: A versatile synthon for constructing complex isoquinoline and tetrahydroisoquinoline derivatives in academic and industrial research.
• Chemical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	1-Oxo-1,2,3,4-Tetrahydro-Isoquinoline-8-Carboxylic Acid Methyl Ester
CAS No.	1250444-46-2
Molecular Formula	C12H11NO3
Molecular Weight	217.22 g/mol
Synonyms	Methyl 1-oxo-1,2,3,4-tetrahydroisoquinoline-8-carboxylate; 8-Methoxycarbonyl-1,2,3,4-tetrahydro-1-isoquinolone; 1,2,3,4-Tetrahydro-1-oxo-8-isoquinolinecarboxylic acid methyl ester; 1-Oxo-1,2,3,4-tetrahydroisoquinoline-8-carboxylic acid methyl ester; 8-(Methoxycarbonyl)-3,4-dihydro-1(2H)-isoquinolinone; 1,2,3,4-Tetrahydroisoquinolin-1-one-8-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1-Oxo-1,2,3,4-Tetrahydro-Isoquinoline-8-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.