Description

1-Bromo-3-((2,2,2-trifluoroethoxy)methyl)benzene is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoroethoxy-benzyl bromide structure. This compound matters for its role as a critical building block in the synthesis of complex molecules, particularly in medicinal chemistry where its halogen and fluorine-containing groups enable precise structural modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the biological activity imparted by the fluorine moiety.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the creation of novel fluorinated polymers and liquid crystals for electronic and optical applications.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic and Industrial R&D: Utilized in research laboratories for exploring new synthetic methodologies and fluorine chemistry.

Basic Information

Item	Details
Product Name	1-Bromo-3-((2,2,2-trifluoroethoxy)methyl)benzene
CAS No.	1248738-39-7
Molecular Formula	C9H8BrF3O
Molecular Weight	269.06 g/mol
Synonyms	3-((2,2,2-Trifluoroethoxy)methyl)bromobenzene; 1-Bromo-3-(2,2,2-trifluoroethoxymethyl)benzene; m-((Trifluoroethoxy)methyl)bromobenzene; (3-Bromophenyl)methyl 2,2,2-trifluoroethyl ether; 3-Bromobenzyl 2,2,2-trifluoroethyl ether; α-(2,2,2-Trifluoroethoxy)-m-bromotoluene
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-((2,2,2-trifluoroethoxy)methyl)benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical properties are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture ingress and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.