Description

4-Bromo-2-Chloro-1H-Benzimidazole is a high-purity halogenated benzimidazole derivative, a crucial advanced intermediate in modern organic synthesis. Its unique molecular structure, featuring both bromo and chloro substituents, makes it a versatile and highly reactive building block for constructing complex heterocyclic systems. This compound is primarily sought after by pharmaceutical research and development teams, as well as agrochemical manufacturers, for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors, antiviral agents, and other biologically active benzimidazole-based compounds.
• Agrochemical Synthesis: Used in the research and development of new fungicides, herbicides, and plant growth regulators that leverage the benzimidazole scaffold.
• Material Science Research: Serves as a building block for creating organic semiconductors, ligands for metal-organic frameworks (MOFs), and specialty polymers.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Dye & Pigment Intermediate: Utilized in the development of specialized colorants and functional dyes due to its robust heterocyclic core.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring functionalized benzimidazole chemistry.

Basic Information

Product Name	4-Bromo-2-Chloro-1H-Benzimidazole
CAS No.	1248548-54-0
Molecular Formula	C7H4BrClN2
Molecular Weight	231.48 g/mol
Synonyms	4-Bromo-2-chloro-1H-benzimidazole; 2-Chloro-4-bromo-1H-benzimidazole; 1H-Benzimidazole, 4-bromo-2-chloro-; 4-Bromo-2-chlorobenzimidazole; 2-Chloro-4-bromobenzimidazole; 4-Br-2-Cl-BIM; BIM-4-Br-2-Cl
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Chloro-1H-Benzimidazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support cGMP compliance for pharmaceutical applications and can tailor quality protocols to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.