Description

7-Bromo-5-Fluoro-2-Methyl-1,2,3,4-Tetrahydro-Isoquinoline is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated tetrahydroisoquinoline core structure. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• CNS Drug Development: Employed in the research of potential therapeutics for neurological and psychiatric disorders due to the privileged tetrahydroisoquinoline structure.
• Oncology Research: Serves as a building block for creating molecules designed to modulate specific biological targets in cancer cells.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying enzyme function and cellular processes.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.

Basic Information

Product Name	7-Bromo-5-Fluoro-2-Methyl-1,2,3,4-Tetrahydro-Isoquinoline
CAS No.	1248202-83-6
Molecular Formula	C10H11BrFN
Molecular Weight	244.10 g/mol
Synonyms	7-Bromo-5-fluoro-2-methyl-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-7-bromo-5-fluoro-2-methylisoquinoline; 2-Methyl-7-bromo-5-fluoro-1,2,3,4-tetrahydroisoquinoline; 7-Bromo-5-fluoro-2-methyl-THIQ; BFMTIQ; CAS 1248202-83-6
EINECS	Contact for details

Quality Control

Our 7-Bromo-5-Fluoro-2-Methyl-1,2,3,4-Tetrahydro-Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.