Description

(S)-1-(1-Benzyl-1H-Indazol-6-Yl)Ethane-1,2-Diol is a high-purity chiral diol building block featuring a benzyl-protected indazole core. This compound is of significant value for pharmaceutical research and development, serving as a critical intermediate in the synthesis of targeted therapeutic agents. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecules with specific stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) targets.
• Asymmetric Synthesis: Utilized as a building block in stereoselective chemical reactions to introduce the (S)-configured diol moiety into more complex molecular architectures.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical entities.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for candidate drugs.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.
• Bioconjugation & Probe Development: Potential use in creating chemical probes or conjugates for biochemical and pharmacological studies due to its functional handles.

Basic Information

Product Name	(S)-1-(1-Benzyl-1H-Indazol-6-Yl)Ethane-1,2-Diol
CAS No.	1247001-61-1
Molecular Formula	C₁₆H₁₆N₂O₂
Molecular Weight	268.31 g/mol
Synonyms	(S)-1-(1-Benzyl-1H-indazol-6-yl)ethane-1,2-diol; (S)-1-(1-Benzyl-1H-indazol-6-yl)glycol; (S)-2-(1-Benzyl-1H-indazol-6-yl)-1,2-ethanediol; 1-Benzyl-6-[(1S)-1,2-dihydroxyethyl]-1H-indazole; (S)-1-(1-Benzylindazol-6-yl)ethane-1,2-diol; 1H-Indazole-6-ethanol, 1-benzyl-α,β-dihydroxy-, (αS)-; Bn-Indazole-(S)-diol
EINECS	Contact for details

Quality Control

Our (S)-1-(1-Benzyl-1H-Indazol-6-Yl)Ethane-1,2-Diol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.