Description

(E)-3-[3,5-Dimethoxy-4-(Trideuteriomethoxy)Phenyl]-2-(Methoxymethyl)Prop-2-Enenitrile is a deuterated aromatic nitrile derivative, a sophisticated intermediate of significant value in advanced chemical synthesis. Its core value proposition lies in the strategic incorporation of deuterium atoms, which are crucial for modifying the pharmacokinetic and metabolic profiles of target molecules. This high-purity compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing deuterated drug candidates, metabolic studies, and high-value specialty chemicals.

Application

• Deuterated Pharmaceutical Intermediate: A key building block for the synthesis of deuterium-labeled active pharmaceutical ingredients (APIs) with enhanced metabolic stability and improved drug half-life.
• Metabolic Research & Tracer Studies: Used as a stable isotope-labeled precursor in mass spectrometry and NMR-based studies to investigate drug metabolism pathways and mechanisms of action.
• Organic Synthesis Reagent: Serves as a versatile intermediate in complex organic synthesis, particularly for constructing functionalized aromatic systems with methoxy and nitrile groups.
• Material Science Research: Potential precursor for the development of novel organic electronic materials or liquid crystals due to its rigid, substituted phenyl core.
• Reference Standard: Supplied as a high-purity certified reference material (CRM) for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	(E)-3-[3,5-Dimethoxy-4-(Trideuteriomethoxy)Phenyl]-2-(Methoxymethyl)Prop-2-Enenitrile
CAS No.	1246833-90-8
Molecular Formula	C14H14D3NO4
Molecular Weight	266.31 g/mol
Synonyms	(E)-3-(3,5-Dimethoxy-4-(trideuteriomethoxy)phenyl)-2-(methoxymethyl)acrylonitrile; 2-Propenenitrile, 3-[3,5-dimethoxy-4-(trideuteriomethoxy)phenyl]-2-(methoxymethyl)-, (E)-; Deuterated Methoxy Phenyl Acrylonitrile Derivative; (E)-Deuterated Aromatic Nitrile Intermediate; 4-(Trideuteriomethoxy)-3,5-dimethoxybenzeneacrylonitrile derivative; (E)-Isomer of deuterated dimethoxybenzylidene malononitrile analog
EINECS	Contact for details

Quality Control

Our (E)-3-[3,5-Dimethoxy-4-(Trideuteriomethoxy)Phenyl]-2-(Methoxymethyl)Prop-2-Enenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation and deuterium incorporation, to ensure compliance with exacting customer specifications. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific regulatory or internal quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.