Description

3-Amino-2,2-Dimethylpropanamide-D6 is a deuterated analog of 3-amino-2,2-dimethylpropanamide, where six hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high analytical accuracy and reproducibility. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers working on drug metabolism, pharmacokinetic (DMPK) studies, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of the non-deuterated parent compound in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical studies.
• Bioanalytical Method Development and Validation: Serves as a reliable reference standard to establish and validate robust, regulatory-compliant analytical methods.
• Isotope Dilution Mass Spectrometry (IDMS): Used in high-precision analytical techniques to minimize matrix effects and improve data accuracy.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities or degradation products.
• Metabolomics Research: Facilitates the accurate measurement of specific metabolites in pathway analysis and biomarker discovery.

Basic Information

Product Name	3-Amino-2,2-Dimethylpropanamide-D6
CAS No.	1246820-97-2
Molecular Formula	C5H6D6N2O
Molecular Weight	122.20 g/mol
Synonyms	3-Amino-2,2-dimethylpropanamide-d6; 2,2-Dimethyl-3-aminopropanamide-d6; 3-Amino-2,2-dimethylpropionamide-d6; Hexadeuterated 3-Amino-2,2-dimethylpropanamide; (Aminomethyl)-D2-neopentylamine-1,1,1,3,3,3-D6 amide; Deuterated AADA; Stable Isotope Labeled AADA
EINECS	Contact for details

Quality Control

Every batch of 3-Amino-2,2-Dimethylpropanamide-D6 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR (¹H, ¹³C), Mass Spectrometry, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), isotopic enrichment (typically ≥98 atom % D), and other critical specifications to meet the stringent requirements of analytical and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.