Description

6,7-Dimethoxy-2-(2,2,3,3,5,5,6,6-Octadeuteriopiperazin-1-Yl)Quinazolin-4-Amine is a deuterated derivative of a quinazoline-based compound, offering enhanced metabolic stability and pharmacokinetic properties for advanced research applications. This high-value compound is critical for use as a stable isotope-labeled internal standard in quantitative bioanalytical methods, ensuring precise and reliable measurement. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism and pharmacokinetics (DMPK) studies for novel therapeutics.

Application

• Primary use as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) bioanalysis.
• Critical for quantitative pharmacokinetic (PK) studies and drug metabolism research to track parent compounds and metabolites.
• Enables highly accurate quantification in complex biological matrices like plasma, serum, and tissue homogenates.
• Supports drug discovery and development programs for kinase inhibitors and other targeted therapies.
• Facilitates regulatory submissions by providing robust analytical data required by agencies like the FDA and EMA.
• Used in mechanistic studies to understand the metabolic fate and disposition of lead compounds.

Basic Information

Product Name	6,7-Dimethoxy-2-(2,2,3,3,5,5,6,6-Octadeuteriopiperazin-1-Yl)Quinazolin-4-Amine
CAS No.	1246820-89-2
Molecular Formula	C₁₄H₁₀D₈N₆O₂
Molecular Weight	318.40 g/mol
Synonyms	6,7-Dimethoxy-2-(octadeuteriopiperazin-1-yl)quinazolin-4-amine; 2-(2,2,3,3,5,5,6,6-Octadeuterio-1-piperazinyl)-6,7-dimethoxy-4-quinazolinamine; Deuterated PD 153035 analog; d8-Piperazinyl Quinazolinamine; 4-Amino-6,7-dimethoxy-2-(2,2,3,3,5,5,6,6-octadeuteropiperazin-1-yl)quinazoline; Stable Isotope Labeled EGFR Inhibitor Metabolite Standard
EINECS	Contact for details

Quality Control

Every batch of our 6,7-Dimethoxy-2-(2,2,3,3,5,5,6,6-Octadeuteriopiperazin-1-Yl)Quinazolin-4-Amine is manufactured under strict quality systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, verified by advanced techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided with each shipment, detailing purity, isotopic enrichment, and solvent content to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.