Description

1-(2,2,3,3,5,5,6,6-Octadeuterio-4-Methylpiperazin-1-Yl)-3-Phenothiazin-10-Ylpropan-1-One is a deuterated derivative of a phenothiazine-based compound, offering enhanced metabolic stability and traceability for advanced research applications. This high-value specialty chemical is critical for pharmaceutical development, particularly in drug metabolism and pharmacokinetics (DMPK) studies, where deuterium labeling provides significant analytical advantages. It is primarily utilized by research institutions, pharmaceutical R&D departments, and contract research organizations (CROs) focused on neuropharmacology and developing novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as an analytical standard for quantifying metabolites and impurities in drug development pipelines.
• Deuterated Internal Standard: Used in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for precise quantitative analysis due to its isotopic labeling.
• Metabolic Pathway Tracing: Facilitates studies on the absorption, distribution, metabolism, and excretion (ADME) of phenothiazine-derived drug candidates.
• Neuropharmacology Research: Employed in preclinical research to investigate the mechanisms and stability of compounds targeting the central nervous system.
• Isotope Effect Studies: Enables research into the kinetic isotope effect (KIE) to understand reaction mechanisms and optimize lead compounds.
• Process Chemistry & Method Development: Aids in developing and validating sensitive analytical methods for quality control in API (Active Pharmaceutical Ingredient) manufacturing.

Basic Information

Product Name	1-(2,2,3,3,5,5,6,6-Octadeuterio-4-Methylpiperazin-1-Yl)-3-Phenothiazin-10-Ylpropan-1-One
CAS No.	1246820-86-9
Molecular Formula	C22H18D8N3OS
Molecular Weight	Contact for details
Synonyms	10-[3-[4-(Methyl-d3)piperazin-1-yl]propionyl]phenothiazine-d5; Deuterated Levomepromazine Metabolite Standard; 1-(Octadeuterio-4-Methylpiperazin-1-yl)-3-(10H-phenothiazin-10-yl)propan-1-one; d8-Levomepromazine Related Compound; 3-Phenothiazin-10-yl-1-(4-methyl-d3-piperazin-1-yl-d5)propan-1-one; NMR Internal Standard 1246820-86-9; Deuterated Phenothiazine Piperazine Derivative
EINECS	Contact for details

Quality Control

Our production of this deuterated compound adheres to strict quality protocols to ensure isotopic purity and chemical integrity, essential for sensitive analytical applications. Each batch is characterized using advanced techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity confirmation is provided with every shipment to support your research and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.