Description

2,5-Pyridinedicarboxylic Acid-D3 is a deuterated derivative of 2,5-pyridinedicarboxylic acid, where three hydrogen atoms are replaced by the stable isotope deuterium. This compound is a critical building block and internal standard in advanced analytical chemistry, particularly for mass spectrometry-based quantification. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require high-purity, isotopically labeled compounds for method development, metabolic studies, and quality control.

Application

• Pharmaceutical Research: Serves as a stable isotope-labeled internal standard for the accurate quantification of APIs and metabolites in bioanalytical studies using LC-MS/MS.
• Metabolite Identification: Used in drug metabolism and pharmacokinetics (DMPK) studies to trace metabolic pathways and identify degradation products.
• Analytical Method Development: Critical for developing and validating sensitive and specific mass spectrometric methods for regulatory compliance (e.g., FDA, EMA).
• Chemical Synthesis: Acts as a deuterated precursor or intermediate in the synthesis of more complex labeled compounds for research.
• Quality Control & Assurance: Employed in high-purity reference standards for calibrating instruments and ensuring analytical accuracy in QC laboratories.
• Material Science Research: Used in the development of novel organic electronic materials and ligands where isotopic labeling is required to study properties.

Basic Information

Product Name	2,5-Pyridinedicarboxylic Acid-D3
CAS No.	1246820-77-8
Molecular Formula	C7D3H2NO4
Molecular Weight	170.13 g/mol (approx.)
Synonyms	2,5-Pyridinedicarboxylic-2,3,6-d3 Acid; Deuterated 2,5-Pyridinedicarboxylic Acid; 2,5-Dicarboxypyridine-d3; Isocinchomeronic Acid-d3; 2,5-Pyridinedicarboxylic Acid (D3); PDCA-d3; 2,5-Pyridinedicarboxylic Acid Deuterated; 2,5-Pyridinedicarboxylic-d3 Acid
EINECS	Contact for details

Quality Control

Our 2,5-Pyridinedicarboxylic Acid-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ²H) for isotopic enrichment verification, HPLC for chemical purity, and mass spectrometry for identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment (²H NMR)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.