Description

6-Amino-3-Methyluracil-D3 is a deuterated derivative of 6-amino-3-methyluracil, a key heterocyclic building block. This compound is specifically valued for its use as a stable isotope-labeled internal standard in quantitative mass spectrometry, ensuring superior accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and impurity profiling.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the precise quantification of its non-deuterated counterpart or related uracil derivatives in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in tracing metabolic pathways, assessing pharmacokinetic parameters, and studying the bioavailability of pharmaceutical compounds where the uracil scaffold is present.
• Bioanalytical Method Development: Essential for validating robust and compliant analytical methods according to FDA, EMA, and ICH guidelines, leveraging its isotopic stability to correct for instrument variability and sample preparation losses.
• Impurity Identification and Quantification: Aids in the detection and measurement of process-related impurities or degradants in active pharmaceutical ingredients (APIs) and finished drug products.
• Stable Isotope Labeling Research: Acts as a valuable tool in mechanistic studies and research exploring the effects of deuterium incorporation on the physical and metabolic properties of molecules.

Basic Information

Item	Details
Product Name	6-Amino-3-Methyluracil-D3
CAS No.	1246820-43-8
Molecular Formula	C5H4D3N3O2
Molecular Weight	144.14 g/mol
Synonyms	6-Amino-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione-d3; 6-Amino-1,3-dimethyluracil-d3; 6-Amino-3-methyl-1H-pyrimidine-2,4-dione-d3; 6-Amino-3-methyluracil (methyl-d3); D3-6-Amino-3-methyluracil; Deuterated 6-Amino-3-methyluracil; [2H3]-6-Amino-3-methyluracil
EINECS	Contact for details

Quality Control

Our 6-Amino-3-Methyluracil-D3 is manufactured under strict quality systems to ensure high chemical and isotopic purity, critical for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing specifications for identity, purity (by HPLC), isotopic enrichment (by MS), and related substances. We adhere to relevant industry guidelines for stable isotope-labeled compounds to guarantee reliable and reproducible performance in your sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.