Description

2-(3,3-Dideuteriooxiran-2-Yl)-6-Fluoro-3,4-Dihydro-2H-Chromene is a deuterated epoxide derivative of a fluorinated chromene, representing a high-value synthetic intermediate in advanced pharmaceutical research. This compound matters for its role in the development of novel therapeutic agents, where the incorporation of deuterium can significantly alter the pharmacokinetic and metabolic profiles of lead molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, specifically for drug discovery programs targeting CNS disorders, oncology, and inflammatory diseases where precise metabolic tuning is critical.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of deuterated drug candidates for improved metabolic stability and extended half-life.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the impact of deuterium substitution on biological activity.
• Isotope Labeling: Acts as a precursor for the preparation of isotopically labeled compounds used in mass spectrometry and metabolic pathway tracing studies.
• Preclinical Development: Employed in the scale-up synthesis of novel chemical entities for pharmacokinetic and toxicology evaluations.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme mechanisms and biological pathways.
• Advanced Material Synthesis: Potential use as a monomer or intermediate in the synthesis of specialized polymers and organic electronic materials.

Basic Information

Item	Details
Product Name	2-(3,3-Dideuteriooxiran-2-Yl)-6-Fluoro-3,4-Dihydro-2H-Chromene
CAS No.	1246820-42-7
Molecular Formula	C13H12D2FO3
Molecular Weight	238.25 g/mol
Synonyms	6-Fluoro-3,4-dihydro-2H-chromen-2-yl-3,3-d2-oxirane; 2-(3,3-Dideuterooxiran-2-yl)-6-fluoro-3,4-dihydro-2H-1-benzopyran; 6-Fluoro-2-(oxiran-2-yl)-3,4-dihydro-2H-chromene-3,3-d2; Deuterated 6-Fluoro-chromene epoxide; (6-Fluoro-3,4-dihydro-2H-chromen-2-yl)oxirane-3,3-d2; 1246820-42-7; FDCO deuterated intermediate
EINECS	Contact for details

Quality Control

Our 2-(3,3-Dideuteriooxiran-2-Yl)-6-Fluoro-3,4-Dihydro-2H-Chromene is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles. We adhere to ISO 9001 standards, and our analytical methods, including NMR, HPLC, and MS, are validated to provide reliable data for critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Deuterium Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.