Description

Diethyl 2-Ethyl-2-Acetamidomalonate-D3 is a deuterium-labeled isotopologue of a key malonate derivative, serving as a crucial building block in synthetic organic chemistry. This labeled compound is specifically designed for applications requiring isotopic tracing, metabolic studies, and the synthesis of deuterated pharmaceutical intermediates. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, isotopically enriched precursors for development and analysis.

Application

• Deuterated Pharmaceutical Intermediate Synthesis: A vital precursor for incorporating deuterium atoms into active pharmaceutical ingredients (APIs) to study metabolism, improve stability, or alter pharmacokinetic profiles.
• Metabolic Pathway Tracing: Used in mass spectrometry and NMR-based studies to track the fate of molecules in biological systems, providing critical data for drug discovery and development.
• Internal Standard for Analytical Chemistry: Serves as a high-purity internal standard in quantitative LC-MS and GC-MS analyses, ensuring accurate measurement of non-labeled analogs in complex matrices.
• Agrochemical Research: Employed in the synthesis of deuterium-labeled pesticides or herbicides for environmental fate studies and residue analysis.
• Material Science Research: Utilized in the development of novel organic electronic materials where deuterium substitution can influence properties like charge transport and stability.
• Academic & Contract Research: A key reagent for universities and CROs conducting fundamental research in synthetic methodology, catalysis, and isotope chemistry.

Basic Information

Product Name	Diethyl 2-Ethyl-2-Acetamidomalonate-D3
CAS No.	1246820-39-2
Molecular Formula	C11H16D3NO5
Molecular Weight	248.28 g/mol (approx.)
Synonyms	Diethyl (2-Ethyl-2-acetamido)malonate-D3; 2-Acetamido-2-ethylmalonic Acid Diethyl Ester-D3; Acetamidomalonic Acid Diethyl Ester, 2-Ethyl-, D3-labeled; Deuterated Diethyl Acetamidomalonate; Diethyl α-Ethyl-α-acetamidomalonate-D3; Ethyl 2-(Acetylamino)-2-ethylpropanedioate-D3; Propanedioic acid, 2-(acetylamino)-2-ethyl-, 1,3-diethyl ester-D3
EINECS	Contact for details

Quality Control

Our Diethyl 2-Ethyl-2-Acetamidomalonate-D3 is produced under controlled conditions to ensure high isotopic and chemical purity, meeting the stringent requirements of research and development. Each batch undergoes rigorous analytical testing, including NMR (for deuterium incorporation verification) and HPLC, to confirm identity, purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment. We adhere to a quality management system to guarantee consistency and traceability for all our specialty and deuterated chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to minimize exposure to moisture and atmospheric contaminants. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure and deuterium labeling pattern
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D (Typical)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.