Description

n-Benzy N,n-Didesmethyl Trimebutine-D5 is a deuterated analog of a key trimebutine metabolite, specifically designed for use as an internal standard in quantitative bioanalytical methods. This high-purity reference material is critical for ensuring the accuracy and reliability of pharmacokinetic and metabolic studies, particularly in drug development and clinical research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in LC-MS/MS analysis.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of trimebutine and its metabolites in biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to track drug absorption, distribution, metabolism, and excretion (ADME) profiles with high specificity.
• Bioanalytical Method Development and Validation: Serves as a critical component in developing robust, reproducible, and regulatory-compliant analytical assays.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Supports studies aimed at optimizing drug dosing and understanding patient variability.
• Pharmaceutical Quality Control: Can be employed in impurity profiling and stability-indicating methods for drug substance and product analysis.
• Forensic and Toxicology Analysis: Aids in the accurate detection and measurement of trimebutine in complex forensic samples.

Basic Information

Product Name	n-Benzy N,n-Didesmethyl Trimebutine-D5
CAS No.	1246820-31-4
Molecular Formula	C22H26D5NO3
Molecular Weight	Contact for details
Synonyms	Trimebutine D5 Metabolite; N-Benzyl-N,N-didesmethyl Trimebutine-d5; Deuterated Trimebutine Metabolite; 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate-d5 (benzyl-labeled); 3,4,5-Trimethoxybenzoic Acid 2-(Dimethylamino)-2-phenylbutyl Ester-d5 (benzyl-labeled); Internal Standard for Trimebutine; ST-2461-d5 (related metabolite)
EINECS	Contact for details

Quality Control

Every batch of n-Benzy N,n-Didesmethyl Trimebutine-D5 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment. Our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical and analytical reference standard applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for purity (by HPLC), isotopic purity (by MS), and identity (by NMR/IR) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.