Description

n-Methylguanidine-D3 Hydrochloride is a deuterium-labeled isotopologue of n-Methylguanidine hydrochloride, a key chemical building block and analytical standard. This compound is specifically valued for its use in quantitative mass spectrometry and metabolic studies, where its stable isotopic label provides a crucial internal reference. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications in drug metabolism and pharmacokinetics (DMPK) research, proteomics, and the development of novel diagnostic assays.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the precise quantification of n-methylguanidine and related metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical compounds, enhancing the accuracy of pharmacokinetic modeling.
• Proteomics & Biomarker Research: Employed in quantitative proteomic workflows, such as stable isotope labeling, to study post-translational modifications like arginine methylation and identify potential disease biomarkers.
• Synthesis of Labeled Compounds: Acts as a deuterated synthon for the preparation of more complex isotopically labeled molecules for use in various research and diagnostic applications.
• Enzymatic & Biochemical Assays: Utilized in studies of enzyme kinetics, particularly for enzymes involved in guanidino compound metabolism, such as guanidinoacetate N-methyltransferase.
• Quality Control & Method Development: Essential for developing, validating, and ensuring the robustness of analytical methods in regulatory-compliant environments.

Basic Information

Product Name	n-Methylguanidine-D3 Hydrochloride
CAS No.	1246820-23-4
Molecular Formula	C₂D₃H₃N₃·HCl
Molecular Weight	116.57 g/mol
Synonyms	1-Methylguanidine-d3 hydrochloride; N-Methyl-d3-guanidine hydrochloride; Guanidine, 1-methyl-d3-, monohydrochloride; (Methyl-d3)guanidine hydrochloride; Deuterated N-Methylguanidine HCl; Isotopic Internal Standard for Methylguanidine; N-Methylguanidine (trideuteromethyl) hydrochloride
EINECS	Contact for details

Quality Control

Our n-Methylguanidine-D3 Hydrochloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and mass spectrometry, to confirm isotopic purity, chemical purity, and identity. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.