Description

Medetomidine-D3 Hydrochloride is a high-purity, isotopically labeled analog of the potent α2-adrenoceptor agonist medetomidine. This deuterated compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, ensuring superior accuracy and reliability in mass spectrometry-based analyses. It is an essential reference material for pharmaceutical research and development, clinical toxicology, and forensic science laboratories requiring precise quantification of medetomidine and its metabolites in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable isotope-labeled internal standard for the accurate quantification of medetomidine in pharmacokinetic, toxicokinetic, and bioequivalence studies.
• Veterinary Pharmaceutical Research: Used in the development and validation of analytical methods for medetomidine, a sedative and analgesic commonly used in veterinary medicine.
• Forensic Toxicology: Critical for the precise measurement of medetomidine concentrations in biological specimens for forensic investigations and clinical casework.
• Metabolite Profiling: Aids in the identification and quantification of medetomidine metabolites in in vitro and in vivo metabolism studies.
• Quality Control & Method Development: Serves as a key component in the development, validation, and routine quality control of analytical assays within pharmaceutical quality control laboratories.
• Clinical Research: Supports research into human exposure and the pharmacological profile of medetomidine and related compounds.

Basic Information

Product Name	Medetomidine-D3 Hydrochloride
CAS No.	1246820-20-1
Molecular Formula	C13H13D3ClN2 • HCl
Molecular Weight	287.22 g/mol
Synonyms	(±)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole-d3 Hydrochloride; Dexmedetomidine-D3 Impurity; Medetomidine-d3 HCl; 1H-Imidazole, 4-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1), labeled with deuterium; Medetomidine (D3) Hydrochloride
EINECS	Contact for details

Quality Control

Our Medetomidine-D3 Hydrochloride is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as chemical purity, isotopic enrichment, and impurity profile. We support compliance with ICH Q2(R1) guidelines for analytical method validation, making this material suitable for regulated bioanalytical work in GLP and GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.