Description

4A€-o-Benzyl Oxyphenbutazone-D9 is a deuterated analog of the non-steroidal anti-inflammatory drug (NSAID) oxyphenbutazone, specifically labeled with nine deuterium atoms. This stable isotope-labeled compound is of critical importance for use as an internal standard in quantitative analytical methods, ensuring high accuracy and reliability in mass spectrometry-based assays. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and quality control for pharmaceutical products.

Application

• Internal Standard for LC-MS/MS Analysis: Essential for the precise quantification of oxyphenbutazone and related metabolites in complex biological matrices such as plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in pharmacokinetic profiling, bioavailability studies, and metabolic stability assays to track and measure the parent drug.
• Bioanalytical Method Development and Validation: Serves as a critical reference material for developing robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Pharmaceutical Quality Control: Supports impurity profiling and assay verification of active pharmaceutical ingredients (APIs) and finished drug products.
• Forensic and Clinical Toxicology: Aids in the accurate detection and measurement of oxyphenbutazone in forensic investigations or therapeutic drug monitoring.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision analytical techniques where the deuterated standard compensates for sample loss and ionization variability.

Basic Information

Product Name	4A€-o-Benzyl Oxyphenbutazone-D9
CAS No.	1246820-01-8
Molecular Formula	C27H21D9N2O5
Molecular Weight	~459.56 g/mol
Synonyms	Oxyphenbutazone-d9; 1-Phenyl-2-(4-benzyl-2,5-dioxo-1-pyrrolidinyl)-1-butanol-d9; 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione 4-(benzyl ether)-d9; Deuterated Oxyphenbutazone Benzyl Ether; Tanderil-d9 (deuterated analog); G-27202-d9; Isotopically Labeled Oxyphenbutazone; [D9]-4A€-o-Benzyl Oxyphenbutazone
EINECS	Contact for details

Quality Control

Every batch of 4A€-o-Benzyl Oxyphenbutazone-D9 is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards for isotopic purity and chemical purity. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.