Description

8-Chloro-11-(2,2,6,6-Tetradeuteriopiperidin-4-Ylidene)-5,6-Dihydrobenzo[1,2]Cyclohepta[2,4-B]Pyridin-3-Ol CAS NO 1246819-99-7 is a deuterated organic compound belonging to a class of complex heterocyclic molecules. This compound is of significant value in pharmaceutical research and development, particularly as a stable isotope-labeled intermediate or reference standard. It is primarily needed by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in advanced drug discovery, metabolic studies, and analytical method development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) or anti-inflammatory targets.
• Deuterated Reference Standard: Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of non-labeled drug compounds in biological matrices.
• Metabolic Pathway Tracing: The deuterium labels enable researchers to track the absorption, distribution, metabolism, and excretion (ADME) profiles of drug candidates in preclinical studies.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to investigate the impact of deuterium incorporation on pharmacokinetics, a strategy known as deuterium-switch.
• Process Chemistry & Impurity Profiling: Acts as a marker or standard for identifying and quantifying process-related impurities and degradation products during API manufacturing.

Basic Information

Product Name	8-Chloro-11-(2,2,6,6-Tetradeuteriopiperidin-4-Ylidene)-5,6-Dihydrobenzo[1,2]Cyclohepta[2,4-B]Pyridin-3-Ol
CAS No.	1246819-99-7
Molecular Formula	C19H14D4ClN2O
Molecular Weight	328.84 g/mol
Synonyms	8-Chloro-11-(2,2,6,6-tetradeuterio-4-piperidylidene)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol; Deuterated Loratadine Derivative; d4-Loratadine Analog; 8-Chloro-11-(perdeuterated piperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-3-ol; 1246819-99-7
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide comprehensive analytical data to support research and regulatory requirements. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles are available upon request. Our quality systems are designed to meet the stringent needs of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.