Description

1-Methyl-5-Amino-1H-Benzimidazole-2-Butanoic Acid Ethyl Ester-D3 is a deuterated benzimidazole derivative, a high-value building block designed for advanced research and development. This compound is critical for applications requiring isotopic labeling, such as in the synthesis of deuterated active pharmaceutical ingredients (APIs) for pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of analytical standards and reference materials.

Application

• Deuterated Pharmaceutical Intermediate: A key synthon for the synthesis of deuterium-labeled drug candidates, enhancing metabolic stability and enabling drug discovery.
• Metabolic Tracer: Used in the development of internal standards for Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) bioanalytical methods.
• Isotope-Labeled Reference Standard: Serves as a certified reference material (CRM) for accurate quantification in regulatory-compliant analytical testing.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to investigate the impact of deuterium incorporation on biological activity.
• Preclinical Development: Facilitates Absorption, Distribution, Metabolism, and Excretion (ADME) studies for new chemical entities (NCEs).

Basic Information

Product Name	1-Methyl-5-Amino-1H-Benzimidazole-2-Butanoic Acid Ethyl Ester-D3
CAS No.	1246819-70-4
Molecular Formula	C₁₄H₁₆D₃N₃O₂
Molecular Weight	261.33 g/mol
Synonyms	Ethyl 4-(5-Amino-1-methyl-1H-benzimidazol-2-yl)butanoate-d3; 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester (deuterated); Deuterated Ethyl 1-Methyl-5-aminobenzimidazole-2-butanoate; 2-(3-Ethoxycarbonylpropyl)-1-methyl-5-aminobenzimidazole-d3; 5-Amino-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester-d3; 1-Methyl-5-amino-2-(3-ethoxy-3-oxopropyl)-1H-benzimidazole-d3; [D3]-Ethyl 1-Methyl-5-aminobenzimidazole-2-butanoate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. We adhere to strict quality management protocols, and our deuterated compounds are characterized using advanced spectroscopic and chromatographic techniques to confirm isotopic purity and chemical identity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.