Description

6-Amino-5-Nitroso-3-Methyluracil-D3 is a deuterated derivative of a nitroso-substituted uracil, serving as a valuable stable-isotope labeled compound for advanced research and development. This compound is particularly significant for its utility as a tracer or internal standard in mass spectrometry, enabling precise quantification and metabolic pathway studies. It is primarily needed by pharmaceutical R&D teams, analytical laboratories, and agrochemical scientists working on nucleoside analogs, enzyme inhibitors, and detailed mechanistic studies.

Application

• As a stable-isotope labeled internal standard for the accurate quantification of its non-deuterated counterpart in LC-MS/MS and GC-MS analyses.
• Use in pharmaceutical research for studying the metabolism, pharmacokinetics, and bioavailability of related uracil-based drug candidates.
• A key synthetic intermediate or reference material in the development of nucleoside analogs with potential antiviral or anticancer activity.
• Employed in biochemical research to investigate enzyme mechanisms involving uracil derivatives, such as dihydropyrimidine dehydrogenase (DPD).
• Application in agrochemical research for the development of novel herbicides or plant growth regulators based on pyrimidine structures.
• As a specialized reagent in academic and industrial R&D for probing reaction mechanisms and synthesizing complex labeled molecules.

Basic Information

Product Name	6-Amino-5-Nitroso-3-Methyluracil-D3
CAS No.	1246819-56-6
Molecular Formula	C5H3D3N4O3
Molecular Weight	173.13 g/mol (for deuterated form)
Synonyms	3-Methyl-6-amino-5-nitrosouracil-d3; 5-Nitroso-6-amino-3-methyluracil-d3; 6-Amino-5-nitroso-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione-d3; 6-Amino-5-nitroso-3-methyl-1H-pyrimidine-2,4-dione-d3; Deutero-6-Amino-5-Nitroso-3-Methyluracil; [2H3]-6-Amino-5-nitroso-3-methyluracil; 6-Amino-5-nitroso-3-methyl-2,4(1H,3H)-pyrimidinedione-d3
EINECS	Contact for details

Quality Control

Our 6-Amino-5-Nitroso-3-Methyluracil-D3 is produced under strict quality management protocols to ensure high isotopic purity and chemical integrity, critical for reliable analytical results. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR and HPLC, to confirm deuterium incorporation and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, purity, and identification data is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.