Description

1H-1-Ethyl-D5 Candesartan Cilexetil is a deuterated isotopologue of the angiotensin II receptor antagonist (ARB) prodrug, Candesartan Cilexetil. This stable isotope-labeled compound is a critical tool for advanced pharmaceutical research and development, enabling precise pharmacokinetic and metabolic studies. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in drug discovery and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a high-purity, non-interfering internal standard for the quantitative bioanalysis of Candesartan in biological matrices like plasma and serum.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in mass spectrometry-based assays to track the absorption, distribution, metabolism, and excretion (ADME) profile of the parent drug.
• Metabolite Identification and Profiling: Aids in the identification and structural elucidation of drug metabolites by providing a stable isotopic reference point.
• Method Development and Validation: Essential for developing and validating robust, sensitive, and specific analytical methods compliant with GLP and GCP standards.
• Clinical Trial Support: Provides reliable quantification data in human clinical trials to determine drug exposure and establish dose-response relationships.
• Reference Material for Quality Control: Acts as a certified reference standard for in-house quality control testing of Candesartan Cilexetil active pharmaceutical ingredients (APIs) and finished dosage forms.

Basic Information

Product Name	1H-1-Ethyl-D5 Candesartan Cilexetil
CAS No.	1246819-47-5
Molecular Formula	C33H29D5N6O6
Molecular Weight	615.68 g/mol
Synonyms	Candesartan Cilexetil-d5; Candesartan Cilexetil (ethyl-d5); (±)-1-Hydroxyethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate (ethyl-d5); (2-Ethoxy-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-1,3-benzodiazol-7-yl)methyl 2-ethoxy-2-oxoethyl-d5 Carbonate; TCV-116-d5; Atacand-d5; BLI-1395-d5; CV-11974-d5 Ester
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality systems to ensure the highest isotopic purity and chemical integrity. Each batch of 1H-1-Ethyl-D5 Candesartan Cilexetil is accompanied by a comprehensive Certificate of Analysis (COA) detailing chemical purity, isotopic enrichment (D5), and results from advanced spectroscopic and chromatographic analyses (NMR, HPLC, LC-MS). We support research compliant with GMP/GLP guidelines, and specifications can be tailored to meet your project's specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or Certificate of Analysis. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D5)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.