Description

Promazine-D6 Hydrochloride is a deuterated internal standard of the phenothiazine derivative, Promazine, specifically designed for high-precision analytical applications. This stable isotope-labeled compound is essential for ensuring accurate quantification and method validation in sophisticated mass spectrometry workflows. It is primarily utilized by pharmaceutical research laboratories, contract research organizations (CROs), and forensic toxicology units requiring reliable reference materials for pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Quantitative Internal Standard for LC-MS/MS: Serves as a critical reference compound for the accurate quantification of Promazine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Drug Metabolism Studies (DMPK): Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic and Clinical Toxicology: Used as a calibrant in assays for the detection and confirmation of phenothiazine drugs in forensic investigations and clinical overdose cases.
• Bioanalytical Method Development and Validation: Provides a stable isotope-labeled analog to correct for matrix effects and ionization efficiency variations, ensuring robust and reproducible analytical methods.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and stability testing of Promazine-based pharmaceutical formulations.
• Research on Deuterium Isotope Effects: Facilitates studies investigating the biochemical and pharmacological impacts of deuterium substitution in drug molecules.

Basic Information

Product Name	Promazine-D6 Hydrochloride
CAS No.	1246819-33-9
Molecular Formula	C17H14D6ClN2S • HCl
Molecular Weight	~ 349.33 g/mol
Synonyms	Promazine-d6 HCl; 10-[3-(Dimethylamino)propyl]phenothiazine-2,3,4,5,6,7-d6 Dihydrochloride; N,N-Dimethyl-3-(phenothiazin-10-yl-2,3,4,5,6,7-d6)propan-1-amine Dihydrochloride; Deuterated Promazine Hydrochloride; Promazine (hexadeuterated) Hydrochloride; Promazine Internal Standard; Promazine-d6 Dihydrochloride
EINECS	Contact for details

Quality Control

Our Promazine-D6 Hydrochloride is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch undergoes comprehensive analysis, including HPLC for chemical purity, NMR and MS for structural confirmation and isotopic enrichment verification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. We adhere to relevant industry standards for reference materials to support your compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.