Description

4-[4-(4'-Chlorobiphenyl-2-Ylmethyl)Piperazin-1-Yl]Benzoic Acid-D8 is a deuterated analog of a key pharmaceutical intermediate, where eight hydrogen atoms are replaced with deuterium. This deuteration is critical for enhancing metabolic stability and pharmacokinetic profiling in drug discovery and development. It is primarily utilized by research chemists and pharmaceutical companies engaged in the synthesis of deuterated drug candidates, analytical method development, and metabolic studies.

Application

• Deuterated Drug Discovery: Serves as a stable, non-radioactive isotopic label in the synthesis of novel deuterated active pharmaceutical ingredients (APIs) to improve drug metabolism and pharmacokinetics (DMPK).
• Metabolic Pathway Studies: Used as an internal standard or tracer in mass spectrometry-based assays to investigate and quantify metabolic pathways and drug degradation products.
• Analytical Reference Standard: Essential for the development and validation of precise analytical methods, including HPLC and LC-MS, for quantifying the non-deuterated parent compound in complex matrices.
• Pharmacokinetic Research: Enables detailed absorption, distribution, metabolism, and excretion (ADME) studies due to its isotopic differentiation from endogenous compounds.
• Chemical Biology Probes: Can be incorporated into molecular probes to study receptor-ligand interactions and biological mechanisms with minimal isotopic interference.

Basic Information

Product Name	4-[4-(4'-Chlorobiphenyl-2-Ylmethyl)Piperazin-1-Yl]Benzoic Acid-D8
CAS No.	1246819-26-0
Molecular Formula	C24H14D8ClN2O2
Molecular Weight	~ 414.94 g/mol
Synonyms	Benzoic acid-D8, 4-[4-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-; 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]benzoic-2,3,5,6-d4 acid-α,α,α,α-d4; Deutetrabenazine Impurity D8; (4'-Chlorobiphenyl-2-ylmethyl)piperazine benzoic acid-D8 derivative; Tetrabenazine metabolite D8 analog; Deuterated BCPMP Benzoic Acid; 4-[4-(4'-Chloro-2-biphenylylmethyl)-1-piperazinyl]benzoic Acid-D8
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and LC-MS. Certificates of Analysis (COA) are provided, detailing parameters such as chemical purity, isotopic enrichment (D-content), and impurity profiles, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.