Description

4-Hydroxy Phenylbutazone-D9 is a high-purity, deuterium-labeled internal standard critical for advanced analytical applications. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities for precise drug quantification and method validation.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of Phenylbutazone and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical Research & Development: Enables precise pharmacokinetic (PK) and pharmacodynamic (PD) studies, supporting drug discovery and development pipelines.
• Bioanalytical Method Validation: Critical for developing and validating robust, GLP-compliant analytical methods in accordance with FDA and EMA guidelines.
• Metabolite Identification & Profiling: Aids in the identification and quantification of hydroxylated metabolites in drug metabolism studies.
• Veterinary Drug Residue Analysis: Applied in testing for Phenylbutazone residues in food-producing animals to ensure food safety and regulatory compliance.
• Forensic & Doping Control Analysis: Supports sensitive detection and confirmation of non-steroidal anti-inflammatory drug (NSAID) use in forensic and anti-doping laboratories.

Basic Information

Product Name	4-Hydroxy Phenylbutazone-D9
CAS No.	1246819-23-7
Molecular Formula	C19H11D9N2O2
Molecular Weight	317.40 g/mol
Synonyms	4-Hydroxyphenylbutazone-d9; 1,2-Diphenyl-4-(2-hydroxyphenyl)-3,5-pyrazolidinedione-d9; Deuterated 4-Hydroxy Phenylbutazone; 4'-OH Phenylbutazone-d9; Oxyphenbutazone-d9 (related metabolite); [2H9]-4-Hydroxyphenylbutazone; 4-HPBZ-d9; Internal Standard for Phenylbutazone LC-MS
EINECS	Contact for details

Quality Control

Our 4-Hydroxy Phenylbutazone-D9 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. We ensure compliance with the stringent requirements for analytical reference standards used in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuteration Degree)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.