Description

Nitazoxanide-D4 is a deuterated isotopologue of the antiparasitic and antiviral agent Nitazoxanide, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is an essential internal standard for the precise quantification of Nitazoxanide and its metabolites in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for pharmaceutical R&D, clinical research, and bioanalytical laboratories focused on drug metabolism and pharmacokinetic (DMPK) studies, ensuring accurate and reliable data.

Application

• Primary use as an internal standard for the quantitative bioanalysis of Nitazoxanide in plasma, serum, and tissue samples.
• Facilitates drug metabolism and pharmacokinetic (DMPK) studies in preclinical and clinical research.
• Enables accurate quantification in LC-MS/MS method development and validation for regulatory submissions.
• Supports research into the mechanism of action and metabolic pathways of Nitazoxanide and related thiazolides.
• Used in pharmaceutical quality control laboratories for method verification and impurity profiling.
• Critical for forensic and anti-doping analysis where precise measurement of drug concentrations is required.

Basic Information

Product Name	Nitazoxanide-D4
CAS No.	1246819-17-9
Molecular Formula	C12H5D4N3O5S
Molecular Weight	329.31 g/mol (deuterated form)
Synonyms	2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide-d4; [²H₄]-Nitazoxanide; Nitazoxanide (phenyl-d4); Deuterated Nitazoxanide; NTZ-D4; Alinia-d4 (labeled analog); 2-Acetoxy-N-(5-nitro-2-thiazolyl)benzamide-d4; 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide (phenyl-d4)
EINECS	Contact for details

Quality Control

Every batch of Nitazoxanide-D4 is manufactured and analyzed under strict quality systems to ensure the highest isotopic purity and chemical integrity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with industry standards for stable isotope-labeled reference materials. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing isotopic enrichment (D-content), chemical purity by HPLC, and confirmatory structural data (NMR, MS).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.