Description

2,2,3,3,5,5,6,6-Octadeuterio-1-Methyl-4-[(2,3,4-Trimethoxyphenyl)Methyl]Piperazine is a deuterium-labeled analog of a key piperazine derivative, offering a stable isotopic tag for advanced research and development. This high-purity compound is essential for applications requiring precise tracking and quantification, such as in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and analytical laboratories focused on drug discovery and development.

Application

• As a stable isotope-labeled internal standard for the accurate quantification of its non-deuterated counterpart in bioanalytical methods using LC-MS/MS.
• In drug metabolism and pharmacokinetics (DMPK) studies to trace the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical candidates.
• For use in deuterium exchange experiments and mechanistic studies in organic and medicinal chemistry research.
• As a critical reference material in the development and validation of regulatory-grade analytical assays for pharmaceutical quality control.
• In the synthesis of more complex deuterium-labeled compounds for use as tracers in various chemical and biological systems.

Basic Information

Product Name	2,2,3,3,5,5,6,6-Octadeuterio-1-Methyl-4-[(2,3,4-Trimethoxyphenyl)Methyl]Piperazine
CAS No.	1246819-10-2
Molecular Formula	C16D8H18N2O3
Molecular Weight	290.39 g/mol (for deuterated form)
Synonyms	1-Methyl-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine-d8; Octadeuterated 1-Methyl-4-(2,3,4-trimethoxybenzyl)piperazine; 1-Methyl-4-(2,3,4-trimethoxybenzyl)piperazine-d8; Deuterated Trimethoprim Intermediate-d8; (2,3,4-Trimethoxybenzyl)-1-methylpiperazine-d8; TMPZ-d8; Isotopically Labeled Piperazine Derivative
EINECS	Contact for details

Quality Control

This deuterated compound is manufactured under strict quality control protocols to ensure isotopic purity and chemical integrity, essential for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic enrichment (atom % D), and impurity profile. Our quality system is designed to meet the rigorous demands of pharmaceutical R&D and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.