Description

2H-2-Ethyl Candesartan is a deuterated analog of the well-known angiotensin II receptor blocker (ARB), Candesartan. This compound is of significant value in pharmaceutical research and development, particularly for use as an internal standard in bioanalytical methods such as LC-MS/MS. It is primarily sought after by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in drug metabolism and pharmacokinetics (DMPK) studies.

Application

• Internal Standard for Bioanalysis: Used as a stable isotope-labeled internal standard in quantitative LC-MS/MS assays for Candesartan in biological matrices (plasma, serum, urine).
• Drug Metabolism Studies (DMPK): Facilitates accurate tracking and quantification of the parent drug Candesartan during absorption, distribution, metabolism, and excretion (ADME) studies.
• Pharmacokinetic Research: Enables precise measurement of drug concentration over time to determine key PK parameters.
• Method Development and Validation: Critical for developing and validating robust, GLP-compliant analytical methods in preclinical and clinical research.
• Reference Standard: Serves as a high-purity chemical reference material for quality control and research purposes.

Basic Information

Product Name	2H-2-Ethyl Candesartan
CAS No.	1246819-02-2
Molecular Formula	C24H19D2N6O3
Molecular Weight	441.47 g/mol
Synonyms	Candesartan-d2 (2-Ethyl); 2-Ethyl-d2 Candesartan; Deuterated Candesartan; (2-Ethyl-4-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid); CV-11974-d2; TCV-116-d2; BLI-049-d2; (±)-1-Hydroxyethyl Candesartan-d2 (related ester metabolite).
EINECS	Contact for details

Quality Control

Our 2H-2-Ethyl Candesartan is manufactured under strict quality control protocols suitable for research applications. Each batch is characterized and tested to ensure high chemical and isotopic purity. A comprehensive Certificate of Analysis (COA) is provided, detailing results for assay, isotopic enrichment, and impurity profiles as determined by advanced techniques like HPLC, MS, and NMR. We support research that demands reliable and traceable reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium, MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.