Description

n-[4-(7-Chloro-5-Hydroxy-2,3,4,5-Tetrahydro-1-Benzazepine-1-Carbonyl)-3-Methylphenyl]-2,3,4,5-Tetradeuterio-6-(Trideuteriomethyl)Benzamide is a deuterated derivative of a benzazepine-based compound, designed for advanced research and development applications. This high-value specialty chemical is critical for studies in pharmacokinetics, metabolism, and bioanalytical method development, where isotopic labeling provides distinct analytical advantages. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in cutting-edge drug discovery and development programs.

Application

• Pharmaceutical Reference Standard: Serves as a certified internal standard for the precise quantification of the parent drug compound in biological matrices using LC-MS/MS.
• Metabolic Studies: Used as a tracer in Absorption, Distribution, Metabolism, and Excretion (ADME) studies to elucidate metabolic pathways and identify metabolites.
• Drug Development Research: Employed in preclinical and clinical research for method validation and ensuring accurate pharmacokinetic (PK) and pharmacodynamic (PD) data.
• Bioanalytical Assay Development: Essential for developing and validating highly sensitive and specific mass spectrometry-based assays in compliance with GLP guidelines.
• Isotope Dilution Mass Spectrometry (IDMS): Acts as the ideal spike-in standard for absolute quantification, minimizing matrix effects and improving analytical accuracy and precision.

Basic Information

Product Name	n-[4-(7-Chloro-5-Hydroxy-2,3,4,5-Tetrahydro-1-Benzazepine-1-Carbonyl)-3-Methylphenyl]-2,3,4,5-Tetradeuterio-6-(Trideuteriomethyl)Benzamide
CAS No.	1246818-18-7
Molecular Formula	C26H21D7ClN2O3
Molecular Weight	Contact for details
Synonyms	Deuterated Benzazepine Carboxamide; 7-Chloro-5-hydroxy-1-{[4-({[6-(trideuteriomethyl)-2,3,4,5-tetradeuteriobenzoyl]amino})methyl)phenyl]carbonyl}-2,3,4,5-tetrahydro-1H-1-benzazepine; D7-Labeled Benzazepine Derivative; Deuterated Internal Standard for [Parent Drug Name]; Benzamide, N-[4-[(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2,3,4,5-tetradeuterio-6-(trideuteriomethyl)-; Stable Isotope-Labeled Analog (D7)
EINECS	Contact for details

Quality Control

Every batch of this deuterated compound is produced and analyzed under strict quality protocols to ensure high isotopic purity and chemical purity, critical for its role as an analytical standard. Our quality commitment includes comprehensive characterization by NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting isotopic enrichment (D7), chemical purity, and confirming identity and purity by orthogonal methods.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic nature, the container must be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D7, MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.