Description

Nicotinamide-D4 n-Oxide is a deuterium-labeled isotopologue of nicotinamide N-oxide, a key metabolite and precursor in biochemical research. This high-purity labeled compound is essential for creating internal standards in mass spectrometry, enabling precise quantification and metabolic pathway tracing. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced pharmacokinetic, metabolomic, and stable isotope tracer studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in bioanalytical method development for nicotinamide and related metabolites.
• Metabolic Pathway Research: Used as a stable isotope tracer to investigate NAD+ biosynthesis, vitamin B3 metabolism, and related enzymatic processes.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug-derived nicotinamide in ADME (Absorption, Distribution, Metabolism, Excretion) studies.
• Clinical Diagnostics Development: Supports the creation of robust assays for measuring vitamin B3 status and associated biomarkers in biological fluids.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Acts as a deuterated probe for structural and dynamic studies in solution.

Basic Information

Product Name	Nicotinamide-D4 n-Oxide
CAS No.	1246817-64-0
Molecular Formula	C6D4H2N2O2
Molecular Weight	140.14 g/mol
Synonyms	Nicotinamide N-Oxide-d4; Pyridine-3-carboxamide-d4 N-Oxide; 3-Carbamoylpyridine-d4 1-Oxide; Deuterated Nicotinamide N-Oxide; Vitamin B3 Amide-d4 N-Oxide; Niacinamide-d4 N-Oxide; [2,4,5,6-D4]Nicotinamide 1-Oxide
EINECS	Contact for details

Quality Control

Our Nicotinamide-D4 n-Oxide is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D-content), chemical purity (HPLC), and identity confirmation (NMR/MS). We adhere to cGMP principles for research chemicals, ensuring traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR / NMR)	Conforms to structure
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.