Description

3-Ethoxy-4-(Ethoxycarbonyl)-Phenyl Acetic Acid-D10 is a high-purity, deuterium-labeled derivative of a key phenylacetic acid intermediate, essential for creating isotopically-labeled compounds with enhanced analytical precision. This compound is specifically designed for use as a critical internal standard in quantitative mass spectrometry, ensuring accurate and reliable measurements in complex matrices. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and contract development and manufacturing organizations (CDMOs) engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and impurity profiling.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, non-interfering reference compound for the precise quantification of its non-deuterated counterpart or related metabolites in biological samples.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to track absorption, distribution, metabolism, and excretion (ADME) of lead compounds.
• Bioanalytical Method Development: Critical for validating sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Isotope Dilution Mass Spectrometry (IDMS): Enables highly accurate quantification by correcting for sample preparation losses and instrument variability.
• Impurity Profiling and Degradation Studies: Helps identify and quantify process-related impurities or degradation products in active pharmaceutical ingredients (APIs).
• Metabolite Identification: Aids in the structural elucidation of drug metabolites by providing a known mass shift reference.

Basic Information

Product Name	3-Ethoxy-4-(Ethoxycarbonyl)-Phenyl Acetic Acid-D10
CAS No.	1246817-24-2
Molecular Formula	C13D10H6O5
Molecular Weight	~258.28 g/mol
Synonyms	Deuterated 3-Ethoxy-4-ethoxycarbonylphenylacetic Acid; [D10]-3-Ethoxy-4-(ethoxycarbonyl)phenylacetic Acid; 2-(3-Ethoxy-4-(ethoxycarbonyl)phenyl)acetic-2,2,3,4,5,6-d6 Acid; Ethyl 2-(carboxymethyl)-6-ethoxybenzoate-D10; 4-Carbethoxy-3-ethoxyphenylacetic Acid-D10; Deuterated EE-PAA; Perdeuterated EECPA; Isotopic Labeling Standard 1246817-24-2
EINECS	Contact for details

Quality Control

Every batch of 3-Ethoxy-4-(Ethoxycarbonyl)-Phenyl Acetic Acid-D10 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure exceptional isotopic purity and chemical identity. Our quality commitment includes comprehensive characterization by NMR, HPLC, and mass spectrometry to confirm deuterium incorporation and chemical purity. Certificates of Analysis (COA) detailing batch-specific results for isotopic purity, chemical purity, and residual solvents are provided and are essential for regulatory submissions in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. For long-term storage, consider storing under inert atmosphere to maintain optimal stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.