Description

8-Chloro-5-Isoquinolinesulfonyl Chloride is a high-purity, bifunctional chemical intermediate essential for advanced organic synthesis. Its dual reactive sites make it a versatile building block for constructing complex heterocyclic scaffolds and functional molecules. This compound is primarily sought by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the development of kinase inhibitors and other biologically active agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially protein kinase inhibitors.
• Chemical Biology Probe Development: Used to create sulfonamide-based probes for studying enzyme function and cellular signaling pathways.
• Agrochemical Research: Serves as a building block for novel active ingredients in crop protection research.
• Material Science: Employed in the synthesis of specialty polymers and advanced organic materials with specific electronic properties.
• Academic & Industrial R&D: Utilized in method development and exploratory synthesis of novel isoquinoline derivatives.

Basic Information

Product Name	8-Chloro-5-Isoquinolinesulfonyl Chloride
CAS No.	1246817-00-4
Molecular Formula	C9H5Cl2NO2S
Molecular Weight	278.11 g/mol
Synonyms	5-Isoquinolinesulfonyl chloride, 8-chloro-; 8-Chloro-5-isoquinolinesulphonyl chloride; 8-Chloroisoquinoline-5-sulfonyl chloride; 1246817-00-4; 8-Chloro-5-sulfochloridoisoquinoline; 8-Chloro-isoquinoline-5-sulfonyl chloride; 8-Chloro-5-(chlorosulfonyl)isoquinoline
EINECS	Contact for details

Quality Control

Our 8-Chloro-5-Isoquinolinesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.