Description

1-(tert-Butyldimethylsilyloxy)-1-(2’-Trimethylsilyl)Ethynyl-Cyclopropane is a sophisticated organosilicon building block featuring both TBS-protected hydroxyl and TMS-protected acetylene functionalities on a strained cyclopropane ring. This compound is valued for its unique reactivity profile, enabling the controlled synthesis of complex molecular architectures. It is primarily sought by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for constructing novel scaffolds and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those requiring cyclopropane rings or advanced alkyne coupling strategies.
• Organic Synthesis Building Block: Used in cross-coupling reactions (e.g., Sonogashira), cycloadditions, and ring-opening polymerizations to introduce functionalized cyclopropane units.
• Materials Science Research: Serves as a precursor for developing novel silicon-containing polymers or hybrid organic-inorganic materials with tailored properties.
• Agrochemical Synthesis: Employed in the research and development of new active ingredients that benefit from the steric and electronic properties of the silyl-protected groups.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in synthetic organic chemistry, exploring new reaction pathways involving protected functional groups.

Basic Information

Product Name	1-(tert-Butyldimethylsilyloxy)-1-(2’-Trimethylsilyl)Ethynyl-Cyclopropane
CAS No.	1246816-70-5
Molecular Formula	C14H28OSi2
Molecular Weight	268.55 g/mol
Synonyms	1-[(tert-Butyldimethylsilyl)oxy]-1-[(trimethylsilyl)ethynyl]cyclopropane; 1-(TBSO)-1-((TMS)ethynyl)cyclopropane; 1-(tert-Butyldimethylsiloxy)-1-(2-trimethylsilylethynyl)cyclopropane; Cyclopropane, 1-[(tert-butyldimethylsilyl)oxy]-1-[(trimethylsilyl)ethynyl]-; 1-(tert-Butyldimethylsilyloxy)-1-(trimethylsilylethynyl)cyclopropane; 1-(TBDMSO)-1-(TMS-ethynyl)cyclopropane
EINECS	Contact for details

Quality Control

Our production of 1-(tert-Butyldimethylsilyloxy)-1-(2’-Trimethylsilyl)Ethynyl-Cyclopropane adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized by NMR (¹H, ¹³C), GC or HPLC analysis, and is supplied with a comprehensive Certificate of Analysis (COA). We support cGMP-compliant manufacturing for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.