Description

1,4-Bis(tert-Boc)Piperazine-D8 is a high-purity, deuterated building block of significant importance in advanced pharmaceutical and agrochemical research. Its core value lies in its role as a stable isotope-labeled intermediate, enabling precise metabolic and pharmacokinetic studies through mass spectrometry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors who require deuterium-labeled standards for drug discovery and development.

Application

• Pharmaceutical Intermediate: A critical deuterated building block for synthesizing novel active pharmaceutical ingredients (APIs) for metabolic studies.
• Mass Spectrometry Standards: Used as an internal standard or reference compound in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for quantitative analysis.
• Drug Metabolism and Pharmacokinetics (DMPK): Facilitates tracing and quantification of drug metabolites in biological systems due to its isotopic label.
• Agrochemical Research: Employed in the development and environmental fate studies of new deuterated pesticide and herbicide candidates.
• Chemical Biology Probes: Serves as a precursor for creating labeled probes to study biological pathways and mechanisms of action.
• Process Chemistry: Used in route scouting and optimization for the synthesis of complex molecules requiring isotopic labeling.

Basic Information

Product Name	1,4-Bis(tert-Boc)Piperazine-D8
CAS No.	1246816-49-8
Molecular Formula	C14H18D8N2O4
Molecular Weight	294.40 g/mol
Synonyms	1,4-Bis(tert-butoxycarbonyl)piperazine-d8; 1,4-Di-Boc-piperazine-d8; 1,4-Bis[(1,1-dimethylethoxy)carbonyl]piperazine-d8; Piperazine-1,4-diyldimethanediyl bis(2-methylpropane-2-carboxylate)-d8; N,N'-Di-Boc-piperazine-d8; BOC-PIPERAZINE-BOC-D8; tert-Butyl 4-[(tert-butoxycarbonyl)amino]piperidine-1-carboxylate-d8 (related); Deuterated Di-Boc Piperazine
EINECS	Contact for details

Quality Control

Our 1,4-Bis(tert-Boc)Piperazine-D8 is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity. Each batch is analyzed using advanced techniques including NMR (¹H, ¹³C) and Mass Spectrometry to confirm deuteration level and chemical purity. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuteration Degree (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.