Description

2,5-Bis(4-Hydroxyphenyl)Piperazine-D4 Dihydrochloride is a deuterated derivative of a key pharmaceutical intermediate, offering enhanced stability and utility in research and development. This compound is critical for advanced analytical applications, particularly in the study of metabolic pathways and pharmacokinetics using mass spectrometry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug discovery and development.

Application

• As an internal standard in quantitative LC-MS/MS analysis for bioanalytical method development and validation.
• For use in deuterium labeling studies to investigate drug metabolism and pharmacokinetics (DMPK).
• In the synthesis of deuterated analogs of active pharmaceutical ingredients (APIs) for tracer and stability studies.
• As a high-purity reference material for quality control and analytical method calibration in pharmaceutical manufacturing.
• For research into receptor-ligand interactions and biochemical assays where isotopic labeling is required.

Basic Information

Product Name	2,5-Bis(4-Hydroxyphenyl)Piperazine-D4 Dihydrochloride
CAS No.	1246816-38-5
Molecular Formula	C16H14D4Cl2N2O2
Molecular Weight	353.25 g/mol
Synonyms	2,5-Bis(4-hydroxyphenyl)piperazine-2,3,5,6-d4 dihydrochloride; 2,5-Bis(p-hydroxyphenyl)piperazine-d4 dihydrochloride; 1,4-Bis(4-hydroxyphenyl)piperazine-d4 dihydrochloride; Deuterated BHP Dihydrochloride; BHP-d4 Dihydrochloride; 2,5-Di(4-hydroxyphenyl)piperazine-d4 dihydrochloride; Piperazine-d4 derivative dihydrochloride
EINECS	Contact for details

Quality Control

Our 2,5-Bis(4-Hydroxyphenyl)Piperazine-D4 Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing identity, purity, assay, and deuterium content is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Content (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.