Description

4-(tert-Butyldiphenylsilyl)Hydroxy Propofol is a key protected intermediate in the synthesis of advanced pharmaceutical compounds. This compound is specifically designed to introduce the propofol pharmacophore while providing a robust silyl protecting group for the hydroxyl functionality, enabling selective reactions in complex synthetic pathways. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of anesthetic agents, novel sedatives, and other proprietary active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of propofol analogs and related anesthetic agents.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex molecules requiring selective protection/deprotection strategies.
• Process Chemistry Development: Serves as a standardized intermediate for scaling up the production of target drug candidates in pilot plants and manufacturing.
• Medicinal Chemistry: Enables the exploration of structure-activity relationships (SAR) by providing a versatile handle for further chemical modification.
• Reference Standard: Employed as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	4-(tert-Butyldiphenylsilyl)Hydroxy Propofol
CAS No.	1246816-09-0
Molecular Formula	C28H34O2Si
Molecular Weight	430.66 g/mol
Synonyms	2,6-Diisopropyl-4-[(tert-butyldiphenylsilyl)oxy]phenol; TBDPS-protected Propofol; 4-(TBDPSO)Propofol; 4-[(tert-Butyldiphenylsilyl)oxy]-2,6-bis(1-methylethyl)phenol; 4-Hydroxy Propofol TBDPS Ether; Propofol 4-TBDPS Ether; 2,6-Diisopropyl-4-(tert-butyldiphenylsiloxy)phenol
EINECS	Contact for details

Quality Control

Our 4-(tert-Butyldiphenylsilyl)Hydroxy Propofol is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality management system supports compliance with cGMP standards for pharmaceutical intermediates, and we can accommodate custom purity specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to fluoride and strong alkali; ensure it is stored separately from such materials to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.