Description

1-[4-Amino-3-Chloro-5-(Trifluoromethyl)Phenyl]-2-[[1,1,1-Trideuterio-2-(Trideuteriomethyl)Butan-2-Yl]Amino]Ethanol:Hydrochloride is a deuterated chemical compound of significant interest in advanced pharmaceutical research and development. This molecule matters because its deuterium-labeled structure offers enhanced metabolic stability, making it a critical intermediate for creating deuterated drug candidates with improved pharmacokinetic profiles. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the synthesis of novel therapeutics, particularly in areas requiring isotopic labeling for mechanism-of-action studies or the development of new chemical entities.

Application

• Deuterated Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key building block in the synthesis of deuterium-labeled pharmaceutical compounds.
• Metabolic Stability Studies: Used in drug discovery to create analogs with potentially longer half-lives and reduced rates of metabolism.
• Isotopic Labeling for Tracing: Employed in pharmacokinetic and pharmacodynamic (PK/PD) research to trace the absorption, distribution, metabolism, and excretion (ADME) of drug candidates.
• Reference Standard Development: Acts as a certified reference material (CRM) or an internal standard for quantitative analytical methods like LC-MS.
• Novel Therapeutic Agent Synthesis: Utilized in medicinal chemistry for the research and development of new drugs targeting various disease pathways.
• Chemical Biology Probes: Applied in the creation of molecular probes to study biological processes and protein interactions.

Basic Information

Product Name	1-[4-Amino-3-Chloro-5-(Trifluoromethyl)Phenyl]-2-[[1,1,1-Trideuterio-2-(Trideuteriomethyl)Butan-2-Yl]Amino]Ethanol:Hydrochloride
CAS No.	1246816-02-3
Molecular Formula	C14H15ClF3N2O • HCl (with D6 isotopic substitution)
Molecular Weight	~374.24 g/mol (for non-deuterated form; contact for exact isotopic weight)
Synonyms	1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-[[1,1,1-trideuterio-2-(trideuteriomethyl)butan-2-yl]amino]ethanol hydrochloride; Deuterated Albuterol Impurity/Intermediate; (RS)-1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)-2-((1,1,1-trideuterio-2-(trideuteriomethyl)butan-2-yl)amino)ethanol hydrochloride; D6-Labeled Salbutamol Related Compound; 4-Amino-3-chloro-α-[[(1,1,1-trideuterio-2-(trideuteriomethyl)butyl)amino]methyl]-5-(trifluoromethyl)benzenemethanol hydrochloride; CAS 1246816-02-3.
EINECS	Contact for details

Quality Control

Our deuterated chemical products are manufactured under strict quality management systems. Each batch of 1-[4-Amino-3-Chloro-5-(Trifluoromethyl)Phenyl]-2-[[1,1,1-Trideuterio-2-(Trideuteriomethyl)Butan-2-Yl]Amino]Ethanol:Hydrochloride undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for isotopic enrichment verification. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.