Description

Diethyl 2-Methyl-D3-2-Propylmalonate is a high-purity, deuterium-labeled malonate ester derivative, serving as a critical building block in advanced synthetic chemistry. Its primary value lies in its role as a stable isotope-labeled intermediate, enabling precise metabolic and pharmacokinetic studies in pharmaceutical research and development. This compound is essential for scientists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require isotopically labeled precursors for tracer studies, analytical standards, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key deuterium-labeled synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in metabolic pathway tracing.
• Metabolic Tracer: Used in mass spectrometry and NMR-based studies to investigate drug metabolism, absorption, and distribution within biological systems.
• Analytical Reference Standard: Serves as a high-purity internal standard for quantitative bioanalytical methods, ensuring accuracy in pharmacokinetic assays.
• Agrochemical Research: Employed in the synthesis of labeled pesticide and herbicide analogs for environmental fate and degradation studies.
• Material Science: Potential precursor for the synthesis of specialty polymers and advanced organic materials requiring specific isotopic labeling.
• Organic Synthesis Building Block: Utilized in multi-step synthetic routes to construct complex molecular architectures, leveraging the malonate moiety for further functionalization.

Basic Information

Item	Detail
Product Name	Diethyl 2-Methyl-D3-2-Propylmalonate
CAS No.	1246815-67-7
Molecular Formula	C11H17D3O4
Molecular Weight	219.30 g/mol (approx.)
Synonyms	Diethyl 2-Methyl-d3-2-propylmalonate; 2-Methyl-d3-2-propylmalonic Acid Diethyl Ester; Propanedioic acid, 2-methyl-2-propyl-1,1,1-d3-, 1,3-diethyl ester; Deuterated Diethyl 2-Methyl-2-propylmalonate; Diethyl (2-Methyl-d3-2-propyl)propanedioate; Malonic acid, 2-methyl-2-propyl-1,1,1-d3-, diethyl ester
EINECS	Contact for details

Quality Control

Every batch of Diethyl 2-Methyl-D3-2-Propylmalonate is manufactured and tested under strict quality management systems to ensure exceptional isotopic and chemical purity. We provide comprehensive Certificates of Analysis (COA) that detail key parameters including assay, isotopic enrichment (D-content), and impurity profiles by advanced analytical techniques. Our commitment to consistent quality and traceability supports critical research and cGMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.