Description

4-[4-(4-Chloro-2,3,5,6-Tetradeuteriophenyl)-4-Hydroxy-1-Oxidopiperidin-1-Ium-1-Yl]-1-(4-Fluorophenyl)Butan-1-One is a high-purity, deuterium-labeled chemical reference standard of significant value in advanced analytical research. This compound, with CAS number 1246815-56-4, is specifically designed to serve as an internal standard for mass spectrometry, enabling precise quantification and method development. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on pharmacokinetics, metabolism studies, and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of parent compounds in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables reliable tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles.
• Bioanalytical Method Development and Validation: Used to establish robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Stable Isotope Dilution Assays: Provides a stable, non-radioactive isotopic label for precise measurement in proteomics and metabolomics research.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants.
• Clinical Research: Supports therapeutic drug monitoring and clinical trial sample analysis requiring high precision.

Basic Information

Product Name	4-[4-(4-Chloro-2,3,5,6-Tetradeuteriophenyl)-4-Hydroxy-1-Oxidopiperidin-1-Ium-1-Yl]-1-(4-Fluorophenyl)Butan-1-One
CAS No.	1246815-56-4
Molecular Formula	C21H20D4ClFNO3
Molecular Weight	401.89 g/mol (deuterated form)
Synonyms	1-(4-Fluorophenyl)-4-[4-hydroxy-4-(4-chloro-2,3,5,6-tetradeuteriophenyl)-1-oxidopiperidin-1-ium-1-yl]butan-1-one; Deuterated Haloperidol Metabolite II Standard; d4-Haloperidol Metabolite; 4-(4-(4-Chloro-2,3,5,6-tetradeuteriophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one N-oxide; Reduced Haloperidol Metabolite-d4; Haloperidol Metabolite II-d4; HP-d4 Metabolite; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of our deuterated standards is produced and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity through rigorous testing via NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific purity, isotopic enrichment, and analytical results. Our quality commitment aligns with the standards expected for GMP/GLP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.