Description

Mazindol-D4 is a deuterated analog of the pharmaceutical compound Mazindol, specifically labeled with four deuterium atoms at the CAS registry number 1246815-50-8. This stable isotope-labeled compound is essential for precise analytical quantification and metabolic studies, serving as a critical internal standard in mass spectrometry. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in bioanalytical method development, pharmacokinetic research, and drug metabolism and pharmacokinetics (DMPK) studies.

Application

• Use as an internal standard for the accurate quantification of Mazindol in biological matrices (e.g., plasma, serum, urine) via LC-MS/MS.
• Facilitation of metabolic pathway elucidation and stable isotope tracer studies in pharmacological research.
• Critical component in the development and validation of GMP-compliant bioanalytical methods for clinical trials.
• Application in forensic toxicology and anti-doping control for precise and legally defensible analyte measurement.
• Supporting drug discovery and development programs where understanding the pharmacokinetic profile of Mazindol is crucial.
• Use in environmental fate studies tracking pharmaceutical residues, leveraging the isotopic label for detection.

Basic Information

Product Name	Mazindol-D4
CAS No.	1246815-50-8
Molecular Formula	C16H10D4ClN3O
Molecular Weight	291.78 g/mol (approximate)
Synonyms	5-(p-Chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol-D4; Mazindol (phenyl-D4); Mazindol-d4; Deuterated Mazindol; [2,3,4,5-D4]-Mazindol; 3H-Imidazo[2,1-a]isoindol-5-ol, 5-(4-chlorophenyl)-2,5-dihydro-, labeled with deuterium; Stable Isotope Labeled Mazindol
EINECS	Contact for details

Quality Control

Our Mazindol-D4 is manufactured under strict quality systems to ensure high chemical and isotopic purity, critical for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity by HPLC, and confirmation of structure. We adhere to relevant industry guidelines for reference standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., argon or nitrogen atmosphere) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Atom % D)	≥98.0% (D4)
Chemical Purity (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.