Description

2-(Trideuteriomethyl)-2,3-Dihydro-1H-Indole CAS NO 1246815-31-5 is a deuterated derivative of 2-methylindoline, where three hydrogen atoms in the methyl group are replaced by the stable isotope deuterium. This deuteration is critical for modifying the metabolic profile and physicochemical properties of the parent molecule, making it an invaluable tool in advanced research and development. It is primarily utilized by pharmaceutical and agrochemical researchers, as well as analytical laboratories, for applications in drug discovery, metabolic studies, and as an internal standard in mass spectrometry.

Application

• Pharmaceutical Research & Drug Discovery: Used as a deuterated building block or intermediate in the synthesis of novel active pharmaceutical ingredients (APIs) to study isotope effects on pharmacokinetics, metabolism, and stability.
• Metabolic Pathway Tracing: Serves as a stable isotope-labeled tracer in metabolic studies to elucidate biochemical pathways and mechanisms of action.
• Analytical Reference Standard: Employed as a high-purity internal standard in quantitative analytical techniques such as LC-MS (Liquid Chromatography-Mass Spectrometry) and GC-MS (Gas Chromatography-Mass Spectrometry) for accurate calibration and measurement.
• Agrochemical Development: Acts as a key intermediate in the research and synthesis of new, potentially more effective or selective crop protection agents.
• Material Science Research: Investigated for its potential use in the development of organic electronic materials due to the indoline core structure.
• Chemical Biology Probes: Utilized in the design of labeled probes for studying protein-ligand interactions and other biological processes.

Basic Information

Product Name	2-(Trideuteriomethyl)-2,3-Dihydro-1H-Indole
CAS No.	1246815-31-5
Molecular Formula	C9H8D3N
Molecular Weight	136.20 g/mol (approx.)
Synonyms	2-(Methyl-d3)-2,3-dihydro-1H-indole; 2-(Trideuteriomethyl)indoline; d3-2-Methylindoline; Indoline-2-methyl-d3; 1H-Indole, 2,3-dihydro-2-(trideuteriomethyl)-; 2-(CD3)-2,3-Dihydro-1H-Indole; Deuterated 2-Methylindoline; 2-Methyl-d3-indoline
EINECS	Contact for details

Quality Control

Every batch of 2-(Trideuteriomethyl)-2,3-Dihydro-1H-Indole is produced and analyzed under strict quality management protocols. We ensure high chemical purity and isotopic enrichment through advanced analytical techniques. Comprehensive testing includes identity confirmation, assay, and determination of isotopic purity (D-enrichment). A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.